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|Section2= |Section3= }} Tetramethylenedisulfotetramine (TETS) is an organic compound that is used as a rodenticide (rat poison).〔(【引用サイトリンク】 Basic datasheet for tetramethylene disulfotetramine )〕 It is an odorless, tasteless white powder that is slightly soluble in water, DMSO and acetone, and insoluble in methanol and ethanol. It is a sulfamide derivative. When crystallized from acetone, it forms cubic crystals with a melting point of 255–260 °C. ==Toxicity and mechanism== TETS is a neurotoxin, causing lethal convulsions. Its effect is similar to picrotoxin, a GABA-A receptor antagonist widely used in research. As one of the most hazardous pesticides, it is 100 times more toxic than potassium cyanide. It might be a more powerful convulsant than the glycine antagonist strychnine. TETS is an non-competitive GABA antagonist and binds irreversibly to neuronal GABA receptors and disables chloride channels, activating neurons. No antidote is known. The lethal dose for humans is 7–10 mg. Poisoning is diagnosed by gas chromatography and the treatment is mainly supportive, with large doses of benzodiazepines and pyridoxine (A form of vitamin B6). It is retained in tissues of poisoned poultry and animals, and can pose severe risk of secondary poisoning. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Tetramethylenedisulfotetramine」の詳細全文を読む スポンサード リンク
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