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PANACREAS
PANACREAS stands for “Integrating chemical approaches to treat pancreatic cancer: making new leads for a cure” and is being supported through Coordination Theme 1 (Health) of the European Community’s FP7.
== Summary ==
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human malignancies and a major health problem. It has been estimated that PDAC causes 34000 deaths per year in the EU alone.〔Ferlay J, et al. Ann Oncol 2007;18:581〕 Despite considerable research efforts in the past decades, conventional treatment approaches, including surgery, radiation, chemotherapy, and combinations of these, have close to no impact on the course of this aggressive neoplasm. Therefore, virtually all of the patients diagnosed with PC develop metastases and die〔Li D, et al. Lancet 2004; 363:1049〕
Given this scenario, the search for new drugs to combat PDAC progression and thus increase patient life expectancy and quality of life has been given high priority.〔Philip PA et al. Consensus Report of the National Cancer Institute Clinical Trials Planning Meeting on Pancreas Cancer Treatment. J Clin Oncol. 2009 Nov 20;27:5660-5669〕 In particular, the National Cancer Institute’s Gastrointestinal Cancer Steering Committee has recently place major emphasis on the enhancement of "research to identify and validate the relevant targets and molecular pathways in PDAC, cancer stem cells, and the microenvironment";
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