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・ Mt. Zion Baptist Church (Canton, Mississippi)
・ Mt William North Mining Project
・ MT Zafirah hijacking
・ MT-03
・ MT-45
・ MT-50 Multitouch Table
・ MT-55
・ MT-ATP6
・ MT-ATP8
・ MT-CYB
・ MT-Energie
・ MT-LB
・ MT-LBu
・ MT-ND1
・ MT-ND2
MT-ND3
・ MT-ND4
・ MT-ND4L
・ MT-ND5
・ MT-ND6
・ MT-Propeller
・ MT-RNR1
・ MT-RNR2
・ Mt-SNP
・ MT-TA
・ MT-TC
・ MT-TD
・ MT-TE
・ MT-TF
・ MT-TG


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MT-ND3 : ウィキペディア英語版
MT-ND3

Mitochondrially encoded NADH dehydrogenase 3 is a protein that in humans is encoded by the mitochondrial gene MT-ND3.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4537 )〕 The ND3 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. Variants of MT-ND3 are associated with Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS), Leigh's syndrome (LS) and Leber's hereditary optic neuropathy (LHON).
== Structure ==

MT-ND3 is located in mitochondrial DNA from base pair 10,059 to 10,404.〔 The MT-ND3 gene produces a 13 kDa protein composed of 115 amino acids.〔(【引用サイトリンク】 work = Cardiac Organellar Protein Atlas Knowledgebase (COPaKB) )〕 MT-ND3 is one of seven mitochondrially-encoded subunits of the enzyme NADH dehydrogenase (ubiquinone). Also known as Complex I, it is the largest of the respiratory complexes. The structure is L-shaped with a long, hydrophobic transmembrane domain and a hydrophilic domain for the peripheral arm that includes all the known redox centres and the NADH binding site. MT-ND3 and the rest of the mitochondrially encoded subunits are the most hydrophobic of the subunits of Complex I and form the core of the transmembrane region.〔

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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