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IRF4 : ウィキペディア英語版
IRF4
__NOTOC__
Interferon regulatory factor 4 also known as ''MUM1'' is a protein that in humans is encoded by the ''IRF4'' gene,〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3662 )〕 located at 6p25-p23.
The ''MUM1'' symbol is polysemous; although it is an older synonym for ''IRF4'' (HGNC:6119), it is also the current HGNC official symbol for melanoma associated antigen (mutated) 1 (HGNC:29641; located at 19p13.3).
== Clinical significance ==

In melanocytic cells the IRF4 gene may be regulated by MITF. IRF4 is a transcription factor that has been implicated in acute leukemia. This gene is strongly associated with pigmentation: sensitivity of skin to sun exposure, freckles, blue eyes, and brown hair color.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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