翻訳と辞書 Words near each other ・ Ireti Doyle ・ Ireton (surname) ・ Ireton, Iowa ・ Ireton, Nova Scotia ・ Iretron ・ IReview ・ Ireviken event ・ Irevna ・ Irewe ・ Irewole ・ IREX ・ Irezumi ・ IRF ・ IRF1 ・ IRF2 ・ IRF3 ・ IRF4 ・ IRF5 ・ IRF6 ・ IRF7 ・ IRF8 ・ IRF9 ・ Irfan ・ Irfan (actor) ・ Irfan (band) ・ Irfan (disambiguation) ・ Irfan (name) ・ Irfan Abidi ・ Irfan Ahmed ・ Irfan Alam Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク IRF3 ： ウィキペディア英語版 IRF3 Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor. == Function == IRF3 is a member of the interferon regulatory transcription factor (IRF) family.〔 IRF3 was originally discovered as a homolog of IRF1 and IRF2. IRF3 has been further characterized and shown to contain several functional domains including a nuclear export signal, a DNA-binding domain, a C-terminal IRF association domain and several regulatory phosphorylation sites. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3661 )〕 IRF3 plays an important role in the innate immune system's response to viral infection. Aggregated MAVS have been found to activate IRF3 dimerization. A recent study shows phosphorylation of innate immune adaptor proteins MAVS, STING and TRIF at a conserved pLxIS motif recruits and specifies IRF3 phosphorylation and activation by the Serine/threonine-protein kinase TBK1, thereby restricts the production of type-I interferons. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「IRF3」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.