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TNNT2
Cardiac muscle troponin T (cTnT), is a protein which in humans is encoded by the ''TNNT2'' gene.〔〔 Cardiac TnT is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration.
The TNNT2 gene is located at 1q32 in the human chromosomal genome, encoding the cardiac muscle isoform of troponin T (cTnT). Human cTnT is an ~36-kDa protein consisting of 297 amino acids including the first methionine with an isoelectric point (pI) of 4.88. It is the tropomyosin- binding and thin filament anchoring subunit of the troponin complex in cardiac muscle cells.〔〔〔 TNNT2 gene is expressed in vertebrate cardiac muscles and embryonic skeletal muscles.〔〔〔
== Structure ==
Cardiac TnT is a 35.9 kDa protein composed of 298 amino acids.〔(【引用サイトリンク】 work = Cardiac Organellar Protein Atlas Database )〕〔 Cardiac TnT is the largest of the three troponin subunits (cTnT, troponin I (TnI), troponin C (TnC)) on the actin thin filament of cardiac muscle. The structure of TnT is asymmetric; the globular C-terminal domain interacts with tropomyosin (Tm), TnI and TnC, and the N-terminal tether which strongly binds Tm. The N-terminal region of TnT is alternatively spliced, accounting for multiple isoforms observed in cardiac muscle.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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