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TNNI3
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TNNI3 : ウィキペディア英語版
TNNI3

Troponin I, cardiac muscle is a protein that in humans is encoded by the ''TNNI3'' gene.
It is a tissue-specific subtype of troponin I, which in turn is a part of the troponin complex.
The ''TNNI3'' gene encoding cardiac troponin I (cTnI) is located at 19q13.4 in the human chromosomal genome. Human cTnI is a 24 kDa protein consisting of 210 amino acids with isoelectric point (pI) of 9.87. cTnI is exclusively expressed in adult cardiac muscle.
== Gene evolution ==

cTnI has diverged from the skeletal muscle isoforms of TnI (slow TnI and fast TnI) mainly with a unique N-terminal extension. The amino acid sequence of cTnI is strongly conserved among mammalian species (Fig. 1). On the other hand, the N-terminal extension of cTnI has significantly different structures among mammal, amphibian and fish.〔

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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