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|Section2= |Section3= }} Integrasone is a polyketide natural product isolated from an unknown fungus that has been shown the inhibit the HIV-1 integrase enzyme.〔Herath, K.; Jayasuriya, H.; Bills, G.; Polishook, J.; Dombrowski, A.; Guan, Z.; Felock, P.; Hazuda, D.; Singh, S. Isolation, Structure, Absolute Stereochemistry and HIV-1 Inhibitory Activity of Integrasone, a Novel Fungal Polyketide. J. Nat. Prod. 2004, 67, 872-874.〕 ==Occurrence== Integrasone occurs naturally in an unidentified sterile fungus. This fungus has been given the label MF6836 by Merck researchers, and was grown on a vermiculite-based solid media, AD2. The methyl ethyl ketone extract of the fungal growth on Sephadex LH 20 (a liquid chromatography medium designed for the separation of small natural products) was then run through both gel permeation chromatography and high performance liquid chromatography to isolate integrasone, which was separated as an amorphous powder at a concentration of 1.8 g/L.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Integrasone」の詳細全文を読む スポンサード リンク
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