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ICP8 : ウィキペディア英語版
ICP8
ICP8, the herpes simplex virus type-1 single-strand DNA-binding protein, is one of seven proteins encoded in the viral genome of HSV-1 that is required for HSV-1 DNA replication. It is able to anneal to single-stranded DNA (ssDNA) as well as melt small fragments of dsDNA;〔 its role is to destabilize duplex DNA during initiation of replication. It differs from helicases because it is ATP- and Mg2+-independent.〔 In cells infected with HSV-1, the DNA in those cells become colocalized with ICP8.
ICP8 is required in late gene transcription, and has found to be associated with cellular RNA polymerase II holoenzyme.
==See also==

*Virus
*Virology

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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