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DPA-714 : ウィキペディア英語版
DPA-714

DPA-714 or ''N'',''N''-diethyl-2-()-5,7-dimethylpyrazolo()pyrimidine-3-acetamide is a selective ligand for the translocator protein (TSPO) currently under evaluation for several clinical applications. For this reason, a practical, multigram synthetic route for its preparation has been described.
The binding affinity of DPA-714 for TSPO is reported as ''K''i = 7.0 ± 0.4 nM.
()DPA-714 is currently under investigation as a potential radiopharmaceutical for imaging TSPO in living systems using positron emission tomography (PET). DPA-714, along with other members of the DPA class of TSPO ligands, has been shown to decrease microglial activation and increase neuronal survival in a quinolinic acid rat model of excitotoxic neurodegeneration, suggesting potential neuroprotective effects.
==See also==

* DPA-713
* translocator protein

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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