|
Bromadoline (U-47931E)〔Unlisted Drugs, volumes 34-35, page 392〕 is an opioid analgesic selective for the mu-opioid receptor developed by the Upjohn company in the 1970s. The drug has a potency lying between that of codeine and morphine being slightly stronger than pentazocine.〔'Differential sensitivity of models of antinociception in the rat, mouse and guinea-pig to IL- and K-opioid receptor agonists' A.G. Hayes, M.J. Sheehan & M.B. Tyers - Br. J. Pharmac. (1987), 91, 823-832〕 It is presumed that the (1R,2R) isomer is the active opioid, overlaying as it does with many other mu agonists.〔J Mol Model 'Insights into subtype selectivity of opioid agonists by ligand-based and structure-based methods' Jianxin Cheng & Guixia Liu & Jing Zhang & Zhejun Xu & Yun Tang〕 Bromadoline is related to AH-7921 and U-47700.〔'Factors Affecting Binding of trans-N-()benzamides at the Primary Morphine receptor' B. Vernon Cheney, Jacob Smuszkovicz, Robert A. Lahtr & Dominic A. Zichi - J Med Chem. 1985 Dec;28(12):1853-64.〕 ==See also== * AH-7921 * U-47700 * Spiradoline * U-50488 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Bromadoline」の詳細全文を読む スポンサード リンク
|