|
Thermostability is the quality of a substance to resist irreversible change in its chemical or physical structure at a high relative temperature. Thermostable materials may be used industrially as fire retardants. A ''thermostable plastic'', an uncommon and unconventional term, is likely to refer to a thermosetting plastic that cannot be reshaped when heated, than to a thermoplastic that can be remelted and recast. Thermostability also commonly refers to a protein resistant to change in its protein structure due to applied heat. ==Thermostable proteins== Most life-forms on Earth live at temperatures of less than 50 °C, commonly from 15 to 50 °C. Above this, thermal energy may cause the unfolding of the protein structure, where the activity of the protein is abolished and a condition understandably deleterious to continuing life-functions. The denaturing of proteins in albumen from a clear, nearly colourless liquid to an opaque white, insoluble gel is a common example of this. Certain thermophilic life-forms exist which can withstand temperatures above this, and have corresponding adaptations to preserve protein function at these temperatures. These can include altered bulk properties of the cell to stabilize all proteins, and specific changes to individual proteins. Examining homologous proteins present in these thermophiles and other organisms reveal only slight differences in the protein structure. One notable difference is the presence of extra hydrogen bonds in the thermophile's proteins—meaning that the protein structure is more resistant to unfolding. The presence of certain types of salt has been observed to alter thermostability in the proteins, indicating that salt bridges likely also play a role in thermostability. Other factors of protein thermostability are compactness of protein structure, oligomerization, and strength interaction between subunits. Thermostable enzymes such as Taq polymerase and Pfu DNA polymerase are used in polymerase chain reactions where temperatures of 94 °C or over are used to melt apart DNA strands. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「thermostability」の詳細全文を読む スポンサード リンク
|