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tecemotide
Tecemotide (INN; emepepimut-S (USAN); formerly known as BLP25 or EMD 531444) is a synthetic lipopeptide that is used as antigen in an investigational therapeutic cancer vaccine (formerly known as Stimuvax, L-BLP25, BLP25 liposomal vaccine or BLP25 liposome vaccine). The investigational therapeutic cancer vaccine is designed to induce a cellular immune response to cancer cells that express MUC1, a glycoprotein antigen that is widely over-expressed on common cancers such as lung cancer, breast cancer, prostate cancer and colorectal cancer. The cellular immune response may lead then to a rejection of tumor tissue expressing the MUC1 antigen.〔(BLP25 liposome vaccine (Tecemotide) long-term safety results from Phase 2b study of patients with stage IIIB and IV non-small cell lung cancer (NSCLC) treated for 2 years or more; World Conference on Lung Cancer, August 2009 )〕
==Collaboration==
Tecemotide was developed – until Clinical trial phase II – by the Canadian biotech company Biomira Inc., which changed in 2007 the company name to Oncothyreon Inc.〔(Biomira announces plan to change name to Oncothyreon )〕 Oncothyreon is now located in Seattle, Washington, USA.
In 2001, Merck KGaA, Darmstadt, Germany, entered into a collaboration and supply agreement with Oncothyreon. In 2007, Merck KGaA acquired the exclusive worldwide marketing rights from Oncothyreon and Merck KGaA is since then entirely responsible for the further clinical development of Tecemotide.〔(Aug 8, 2007, Biomira and Merck KGaA sign amended and restated collaboration and supply agreements related to Stimuvax )〕 In 2008, Merck KGaA acquired the manufacturing rights for Tecemotide from Oncothyreon.〔(Dec 18, 2008, Merck KGaA acquires manufacturing rights for Stimuvax from Oncothyreon )〕 In 2011, Ono Pharmaceutical Co., Ltd., Japan, acquired a co-development and co-marketing license for Tecemotide in Japan and Merck KGaA received an upfront payment of 5 million Euros.〔(Merck KGaA press release from October 4, 2011 )〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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