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taxane
Taxanes are diterpenes produced by the plants of the genus ''Taxus'' (yews) featuring a taxadiene core. The are widely used as chemotherapy agents. Taxane agents include paclitaxel (Taxol) and docetaxel (Taxotere). In 2010 another Taxane, cabazitaxel was FDA approved to treat hormone-refractory prostate cancer.
Taxanes present difficulties in formulation as medicines because they are poorly soluble in water.
== Production ==
As their name suggests, taxanes were first derived from natural sources, but some have been synthesized artificially. Paclitaxel was originally derived from the Pacific yew tree. Taxanes are difficult to synthesize because of their numerous chiral centres — Taxol has 11 of these.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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