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propylhexedrine : ウィキペディア英語版
propylhexedrine

Propylhexedrine (Benzedrex, Obesin) is a stimulant drug that is used medicinally as a nasal decongestant (for relief of congestion due to colds, allergies and allergic rhinitis) and recreationally for its psychostimulant effects. Being a vasoconstrictor used to decongest nasal mucosa, it is administered by inhalation.
Propylhexedrine is most commonly found in over-the-counter Benzedrex inhalers. Benzedrex was first manufactured by Smith, Kline and French after the Benzedrine inhaler, which contained racemic amphetamine, became unavailable following the placement of amphetamines on the US Schedule II status (highest abuse potential, yet with accepted medicinal uses). Benzedrex is currently manufactured by B.F. Ascher & Co. Inc. Pharmaceuticals. Propylhexedrine has also seen use in Europe as an appetite suppressant under the trade name Obesin and in the anticonvulsant preparation barbexaclone its ''S''-isomer (levopropylhexedrine or L-propylhexedrine) is bonded with phenobarbital for the purpose of offsetting the barbiturate-induced sedation.〔 Levopropylhexedrine is also used as an anorectic under the brand name Eventin.〔(【引用サイトリンク】url=http://www.drugs.com/international/eventin.html )
== Chemistry ==
Free base propylhexedrine is a volatile, oily liquid at room temperature. The slow vaporization of free base propylhexedrine allows it to be administered via inhalation.〔(Nasal Inhaler ), 〕 Acid salts of propylhexedrine (such as propylhexedrine HCl) often present as a stable, clear to off-white crystalline powder that readily dissolves in water.
Propylhexedrine is structurally similar to methamphetamine and other phenylethylamines, with the only structural difference being the substitution of an alicyclic cyclohexyl group for the aromatic phenyl group of phenethylamine. Propylhexedrine is not an amphetamine, nor even a phenethylamine, but instead can be referred to as a cycloalkylamine. Because propylhexedrine is not an amphetamine, it is somewhat less potent than structurally similar amphetamines such as methamphetamine.
Propylhexedrine is a chiral compound (the α-carbon is chiral), and active ingredient contained in Benzedrex inhalers is racemic (''RS'')-propylhexedrine as the free base. (''S'')-Propylhexedrine, also known as levopropylhexedrine, is believed to be the more biologically active isomer of the two. (''S'')-Propylhexedrine can be synthesized from dextromethamphetamine.〔(Textbook of organic medicinal and pharmaceutical chemistry ), Charles Owens Wilson, Ole Gisvold, Robert F. Doerge, page 491〕

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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