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phosphatidylinositol : ウィキペディア英語版
phosphatidylinositol

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Phosphatidylinositol consists of a family of lipids as illustrated on the right, a class of the phosphatidylglycerides. In such molecules the isomer of the inositol group is assumed to be the myo- conformer unless otherwise stated. Typically phosphatidylinositols form a minor component on the cytosolic side of eukaryotic cell membranes. The phosphate group gives the molecules a negative charge at physiological pH.
The form of phosphatidylinositol comprising the isomer ''muco''-inositol acts as a sensory receptor in the taste function of the sensory system. In this context it is often referred to as PtdIns, but that does not imply any molecular difference from phosphatidylinositols comprising the myo- conformers of inositol.
The phosphatidylinositol can be phosphorylated to form phosphatidylinositol phosphate (PI-4-P, referred to as PIP in close context or informally), phosphatidylinositol bisphosphate (PIP2) and phosphatidylinositol trisphosphate (PIP3). All lipids based on phosphatidylinositol are known as inositides, or sometimes phosphoinositides.
==Biosynthesis==

The neurologically important PtdIns are synthesized as a liquid crystalline region in the outer lemma of the cilia of the sodium path (Na path) sensory receptors exposed to the mucosa in mammals and some other vertebrates (Family Chordata). This specific form of phosphatidylinositol formed with ''muco''-Inositol (CAS 488-55-1) is NOT shown at right. This compound forms the sensory receptor of the sodium path under the molecular biochemical model of the gustatory modality.
The synthesis of phosphatidylinositol in the laboratory is catalyzed by phosphatidylinositol synthase and involves CDP-diacylglycerol and L-''myo''-inositol.〔

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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