翻訳と辞書 Words near each other ・ "O" Is for Outlaw ・ "O"-Jung.Ban.Hap. ・ "Ode-to-Napoleon" hexachord ・ "Oh Yeah!" Live ・ "Our Contemporary" regional art exhibition (Leningrad, 1975) ・ "P" Is for Peril ・ "Pimpernel" Smith ・ "Polish death camp" controversy ・ "Pro knigi" ("About books") ・ "Prosopa" Greek Television Awards ・ "Pussy Cats" Starring the Walkmen ・ "Q" Is for Quarry ・ "R" Is for Ricochet ・ "R" The King (2016 film) ・ "Rags" Ragland ・ ! (album) ・ ! (disambiguation) ・ !! ・ !!! ・ !!! (album) ・ !!Destroy-Oh-Boy!! ・ !Action Pact! ・ !Arriba! La Pachanga ・ !Hero ・ !Hero (album) ・ !Kung language ・ !Oka Tokat ・ !PAUS3 ・ !T.O.O.H.! ・ !Women Art Revolution Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク orosomucoid ： ウィキペディア英語版 orosomucoid Orosomucoid (''ORM'') or alpha-1-acid glycoprotein (''α1AGp'',〔 ''AGP'' or ''AAG'') is an acute phase (acute phase protein) plasma alpha-globulin glycoprotein and is modulated by two polymorphic genes. It is synthesized primarily in hepatocytes and has a normal plasma concentration between 0.6-1.2 mg/mL (1-3% plasma protein). Plasma levels are affected by pregnancy, burns, certain drugs, and certain diseases, particularly HIV.〔 The only established function of ORM is to act as a carrier of basic and neutrally charged lipophilic compounds. In medicine, it is known as the primary carrier of basic (positively charged) drugs (whereas albumin carries acidic (negatively charged) and neutral drugs), steroids, and protease inhibitors.〔 Aging causes a small decrease in plasma albumin levels; if anything, there is a small increase in alpha-1-acid glycoprotein. The effect of these changes on drug protein binding and drug delivery, however, appear to be minimal. AGP shows a complex interaction with thyroid homeostasis: ORM in low concentrations was observed to stimulate the thyrotropin (TSH) receptor and intracellular accumulation of cyclic AMP. High AGP concentrations, however, inhibited TSH signalling.〔Zimmermann-Belsing T, Rasmussen AK, Feldt-Rasmussen U, Bøg-Hansen TC. The influence of alpha1-acid glycoprotein (orosomucoid) and its glycoforms on the function of human thyrocytes and CHO cells transfected with the human TSH receptor. Mol Cell Endocrinol. 2002 Feb 25;188(1-2):241-51. PMID 11911961〕〔Dietrich JW, Landgrafe G, Fotiadou EH. TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis. J Thyroid Res. 2012;2012:351864. doi: 10.1155/2012/351864. Epub 2012 Dec 30. PMID 23365787〕 Alpha-1-acid glycoprotein has been identified as one of four potentially useful circulating biomarkers for estimating the five-year risk of all-cause mortality (the other three are albumin, very low-density lipoprotein particle size, and citrate). Orosomucoid increases in amount in obstructive jaundices while diminishes in hepatocellular jaundice and in intestinal infections. == References == 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「orosomucoid」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.