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depside
A depside is a type of polyphenolic compound composed of two or more monocyclic aromatic units linked by an ester bond. Depsides are most often found in lichens, but have also been isolated from higher plants, including species of the Ericaceae, Lamiaceae, Papaveraceae and Myrtaceae.〔 〕 Depsides have antibiotic, anti-HIV, antioxidant, and anti-proliferative activity.〔〔Nielsen J, Nielsen PH, Frisvad JC.(1998). Fungl depside, guisinol, from a marine derived strain of ''Emericella unguis''. ''Phytochemistry'' 50: 263-265.〕 As inhibitors of prostaglandin synthesis and leukotriene B4 biosynthesis, depsides are potent non-steroidal anti-inflammatories.〔Oettl SK, Gerstmeier J, Khan SY, Wiechmann K, Bauer J, Atanasov AG, Malainer C, Awad EM, Uhrin P, Heiss EH, Waltenberger B, Remias D, Breuss JM, Boustie J, Dirsch VM, Stuppner H, Werz O, Rollinger JM. (Imbricaric Acid and Perlatolic Acid: Multi-Targeting Anti-Inflammatory Depsides from Cetrelia monachorum ).. PLoS One. 2013 Oct 9;8(10):e76929. PubMed (PMID 24130812 ).〕
A depsidase is a type of enzyme that cuts depside bonds. One such enzyme is tannase.〔(The esterase and depsidase activities of tannase. E. Haslam and J. E. Stangroom, Biochem J. 1966 April; 99(1): 28–31. )〕
Gyrophoric acid, found in the lichen ''Cryptothecia rubrocincta'', is a depside.
==See also==
*Salsalate homodimer formed from self-condensation of salicylic acid to form ester linkage.
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