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cryptdin
Cryptdin is mammalian defensins of the alpha subfamily that are produced within the mouse small bowel. The word is a portmanteau that combines the terms 'crypt' and 'defensin'. Formally, in the scientific literature they are known as mouse enteric alpha defensins.
==Variation==
Cryptdins are the protein products of a related family of highly polymorphic genes that are specifically expressed by mouse Paneth cells at the base of intestinal crypts. They were first characterized as products of cDNAs derived from mouse small intestinal RNA. To date, over 25 cryptdin-encoding transcripts have been described. Despite the expression of a relatively large number of cryptdin isoforms, only 6 cryptdins have been isolated at the protein level. Conventional nomenclature labels the isoforms cryptdins-1 through -6 in order of discovery. The primary structures of cryptdin isoforms are highly homologous. Most differences between the isoforms lie in the identity of residues at the N- and C-termini.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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