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Buspirone ( ), trade name Buspar, is an anxiolytic psychotropic drug of the azapirone chemical class.〔 (【引用サイトリンク】 title=Commonly Prescribed Psychotropic Medications ) 〕 It is primarily used to treat generalized anxiety disorder (GAD). Unlike most drugs predominantly used to treat anxiety, buspirone's pharmacology is not related to benzodiazepines or barbiturates, and so does not carry the risk of physical dependence and withdrawal symptoms for which those drug classes are known. Buspirone was first identified by a team at Mead Johnson in 1972, but was not patented until 1975.〔Psychosedative agents. 2. 8-(4-Substituted 1-piperazinylalkyl)-8-azaspiro()decane-7,9-diones Yao-Hua Wu, J.W.Rayburn, L.E.Allen, H.C.Ferguson, J.W.Kissel J.Med.Chem., 1972, 15 (5) pages 477–479〕〔US Patent 3907801 N-(8 (4-pyridyl-piperazino)-alkyl(9 -azaspiroalkanediones〕 In 1986, Bristol-Myers Squibb gained Food and Drug Administration (FDA) approval for buspirone in the treatment of GAD. The patent placed on buspirone expired in 2001 and buspirone is now available as a generic drug. ==Medical uses== Buspirone is approved in the United States by the FDA for the treatment of anxiety disorders and the short-term relief of the symptoms of anxiety.〔 Likewise in Australia, buspirone is licensed for the treatment of anxiety disorders.〔 In the United Kingdom, buspirone is indicated only for the short-term treatment of anxiety.〔〔 〕 Although not approved for this indication, studies such as STAR *D have shown buspirone to be an effective augmentation agent alongside treatment with selective serotonin reuptake inhibitors (SSRIs) for clinical depression and is also used to counter the sexual side effects (anorgasmy and impotence) of the SSRI. Several clinical trials, most randomised double-blind trials (and in one buspirone was used as an adjunct to atomoxetine) and one open-label, have been conducted to evaluate the utility of buspirone in the treatment of attention deficit hyperactivity disorder with mostly positive results. Buspirone is also used in the treatment of mild to moderate cerebellar ataxia.〔http://archneur.jamanetwork.com/article.aspx?articleid=593671〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「buspirone」の詳細全文を読む スポンサード リンク
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