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・ Zalu Ab Rural District
・ Zalu Ab, Ilam
・ Zalu Ab, Kermanshah
・ Zalu Band
・ Zalu Bolaghi
・ Zaluchye
・ Zalud House
・ Zalug
・ Zaluki
・ Zalul Environmental Association
・ Zalun
・ Zalun Township
・ Zalunabad
・ Zaluscodes
・ Zalutschia
Zalutumumab
・ Zalutyń
・ Zaluzania
・ Zaluzhany
・ Zaluzianskya
・ Zalužani
・ Zalužany
・ Zalužice
・ Zalužje
・ Zalužje (Bratunac)
・ Zalužje, Nevesinje
・ Zalužnica
・ Zalužnje
・ Zalvation
・ Zalve Parish


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Zalutumumab : ウィキペディア英語版
Zalutumumab

Zalutumumab (proposed trade name HuMax-EGFr) is a fully human IgG1 monoclonal antibody (mAb) directed towards the epidermal growth factor receptor (EGFr). It is a product developed by Genmab in Utrecht, the Netherlands. Specifically, zalutumumab is designed for the treatment of squamous cell carcinoma of the head and neck (SCCHN), a type of cancer.
The current treatment for SCCHN includes tyrosine kinase inhibitors and human monoclonal antibodies.
== Mechanism of action ==
Zalutumumab works through inhibition of the EGFr signal. The EGFr is a receptor tyrosine kinase. Its structure includes an extracellular binding domain, a transmembrane lipophilic segment, and an intracellular tyrosine kinase domain.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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