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Testin
Testin also known as TESS is a protein that in humans is encoded by the ''TES'' gene located on chromosome 7. TES is a 47 kDa protein composed of 421 amino acids found at focal adhesions and is thought to have a role in regulation of cell motility. In addition to this, TES functions as a tumour suppressor. The ''TES'' gene is located within a fragile region of chromosome 7, and the promoter elements of the ''TES'' gene have been shown to be susceptible to methylation - this prevents the expression of the TES protein. TES came to greater prominence towards the end of 2007 as a potential mechanism for its tumour suppressor function was published.
== Domain organisation ==
Tes is composed of the following domains:
The structures of the Cysteine rich domain and the PET domain are not known. LIM domains, however, are known as modulators of protein interactions. LIM domain consist of 2 zinc fingers separated by 2 hydrophobic amino acids (generally a phenylalanine and then a leucine).
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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