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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク SPOP ： ウィキペディア英語版 SPOP :''Disambiguation: For the animated series see She-Ra: Princess of Power.'' Speckle-type POZ protein is a protein that in humans is encoded by the ''SPOP'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8405 )〕 This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.〔 == Clinical relevance == Mutations in ''SPOP'' lead to a type of prostate tumor thought to be involved in about 15% of all prostate cancers. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「SPOP」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.