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・ S100A10
・ S100A11
・ S100A12
・ S100A13
・ S100A14
・ S100A15
・ S100A16
・ S100A2
・ S100A3
・ S100A4
・ S100A5
・ S100A6
・ S100A7
・ S100A8
・ S100A9
S100B
・ S100G
・ S100P
・ S104
・ S105
・ S105 Nansha Port Expressway
・ S109
・ S11
・ S11 (classification)
・ S11 (protest)
・ S11 (Rhine-Ruhr S-Bahn)
・ S11 highway (Georgia)
・ S11 House
・ S110
・ S110 (Amsterdam)


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S100B : ウィキペディア英語版
S100B

S100 calcium-binding protein B (S100B) is a protein of the S-100 protein family.
S100 proteins are localized in the cytoplasm and nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3.
== Function ==
S100B is glial-specific and is expressed primarily by astrocytes, but not all astrocytes express S100B. It has been shown that S100B is only expressed by a subtype of mature astrocytes that ensheath blood vessels and by NG2-expressing cells.
This protein may function in neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. In the developing CNS it acts as a neurotrophic factor and neuronal survival protein. In the adult organism it is usually elevated due to nervous system damage, which makes it a potential clinical marker.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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