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In genetics, rs4680 (Val158Met) is a genetic variant. It is a single nucleotide polymorphism (SNP) in the ''COMT'' gene that codes catechol-''O''-Methyltransferase. The single nucleotide substitution between G--> A results in an amino acid change from valine to methionine at codon 158. The A or Met allele is associated with lower enzymatic activity (due to thermoinstability), and with exploratory behaviour. The polymorphism has been much studied in schizophrenia research but as of November 2011 meta-analysis in the ''SzGene'' database shows no or very little effect.〔http://www.szgene.org/meta.asp?geneID=420&polyID=2954〕 Several personality genetics studies have examined the association of the polymorphism with personality traits. == References == 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Rs4680」の詳細全文を読む スポンサード リンク
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