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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク RWJ-51204 ： ウィキペディア英語版 RWJ-51204 RWJ-51204 is an anxiolytic drug used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. RWJ-51204 is a nonselective partial agonist at GABAA receptors.〔Atack JR. Anxioselective compounds acting at the GABA(A) receptor benzodiazepine binding site. ''Current Drug Targets. CNS and Neurological Disorders''. 2003 Aug;2(4):213-32.〕 It produces primarily anxiolytic effects at low doses, with sedative, ataxia and muscle relaxant effects only appearing at some 20x the effective anxiolytic dose.〔Dubinsky B, Vaidya AH, Rosenthal DI, Hochman C, Crooke JJ, DeLuca S, DeVine A, Cheo-Isaacs CT, Carter AR, Jordan AD, Reitz AB, Shank RP. 5-ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydrobenzo()imidazo()pyridine-4-N-(2-fluorophenyl)carboxamide (RWJ-51204), a new nonbenzodiazepine anxiolytic. ''Journal of Pharmacology and Experimental Therapeutics''. 2002 Nov;303(2):777-90.〕 It was discovered by researchers at the pharmaceutical company Johnson & Johnson,〔Reitz AB, Jordan AD, Sanfilippo PJ, and Vavouyios-Smith A (1998) (U.S. Patent 5,817,668 ).〕〔Cohen JH, Maryanoff CA, Stefanik SM, Sorgi KL, Villani FJ. Process research for the synthesis of RWJ-51204, a novel anxiolytic agent. ''Organic Process Research & Development''. 1999; 3(4):260-265.〕 but its development has been discontinued. == References == 〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「RWJ-51204」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.