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・ RAB3D
・ RAB3GAP1
・ RAB3GAP2
・ RAB3IP
・ RAB40A
・ RAB4A
・ RAB5A
・ RAB5B
・ RAB5C
・ RAB6A
・ RAB6B
・ RAB6C
・ RAB7A
・ RAB7B
・ RAB7L1
RAB8A
・ RAB8B
・ RAB9A
・ Raba
・ Raba (river)
・ Raba Bar Jeremiah
・ Raba bar Rav Huna
・ Raba Niżna
・ Raba Wyżna
・ Raba, Indonesia
・ Rabaa Al-Adawiya Mosque
・ Rabab Eid
・ Rabab Fetieh
・ Rababah
・ Rababe Arafi


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RAB8A : ウィキペディア英語版
RAB8A

Ras-related protein Rab-8A is a protein that in humans is encoded by the ''RAB8A'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4218 )
== Function ==

The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.〔

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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