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| Predictprotein ： ウィキペディア英語版 |
Predictprotein
PredictProtein (PP) is an automatic service that searches up-to-date public sequence databases, creates alignments, and predicts aspects of protein structure and function. Users send a protein sequence and receive a single file with results from database comparisons and prediction methods. PP went online in 1992 at the European Molecular Biology Laboratory; since 1999 it has operated from Columbia University and in 2009 it moved to the Technische Universität München. Although many servers have implemented particular aspects, PP remains the most widely used public server for structure prediction: over 1.5 million requests from users in 104 countries have been handled; over 13000 users submitted 10 or more different queries. PP web pages are mirrored in 17 countries on 4 continents. The system is optimized to meet the demands of experimentalists not experienced in bioinformatics. This implied that we focused on incorporating only high-quality methods, and tried to collate results omitting less reliable or less important ones.
== Attempt to simplify output by incorporating a hierarchy of thresholds ==
The attempt to ‘pre-digest’ as much information as possible to simplify the ease of interpreting the results is a unique pillar of PP. For example, by default PP returns only those proteins found in the database that are very likely to have a similar structure to the query protein. Particular predictions, such as those for membrane helices, coiled-coil regions, signal peptides and nuclear localization signals, are not returned if found to be below given probability thresholds.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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