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|Section2= |Section3= |Section4= |Section5= |Section6= |Section7= |Section9= }} Parthenolide is a sesquiterpene lactone of the germacranolide class which occurs naturally in the plant feverfew (''Tanacetum parthenium''), after which it is named. It is found in highest concentration in the flowers and fruit. Feverfew is used in herbalism and is purportedly useful for a variety of ailments. Many vendors of feverfew remedies specify the content of parthenolide in their products, because it is believed to be the primary chemical constituent responsible for biological activity.〔(Parthenolide ) from Fermentek〕 Lack of solubility in water and bioavailability limits the potential of parthenolide as a drug. Drug researchers are trying to develop synthetic analogs instead that will be absorbed to a more useful extent.〔(【引用サイトリンク】 Orally Bioavailable Parthenolide Analog Eradicates Leukemia Stem Cells )〕 ==''In vitro'' biological activities== Parthenolide has a variety of reported ''in vitro'' biological activities, including: *Modulation of the NF-κB-mediated inflammatory responses in experimental atherosclerosis. *Inducing apoptosis in acute myelogenous leukemia (AML) cells, leaving normal bone marrow cells relatively unscathed. Moreover, the compound may get at the root of the disease because it also kills stem cells that give rise to AML. Parthenolide is under consideration as a potential cancer drug in combination with sulindac. *Activity against a parasite ''Leishmania amazonensis''. *Microtubule-interfering activity. *Anti-inflammatory and anti-hyperalgesic effects. *Blocking lipopolysaccharide-induced osteolysis through the suppression of NF-κB activity. *inducing apoptosis and production of reactive oxygen species in high-risk pre-B leukemia cells. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Parthenolide」の詳細全文を読む スポンサード リンク
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