|
Paroxetine (also known by the trade names Paxil and Seroxat, among others) is an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) type. Paroxetine is used to treat major depression, obsessive-compulsive disorder, panic disorder, social anxiety, posttraumatic stress disorder, generalized anxiety disorder and vasomotor symptoms (e.g. hot flashes and night sweats) associated with menopause in adult outpatients. Differences between newer antidepressants are usually fairly subtle and mostly confined to side effects. Paroxetine shares the common side effects and contraindications of other SSRIs. Discontinuing paroxetine is associated with a high (7%) risk of withdrawal syndrome. It may be associated with a slightly increased risk of birth defects. Several studies have associated paroxetine with suicidal thinking and behavior in teenagers.〔McGoey, Linsey; Jackson, Emily. ("Seroxat and the suppression of clinical trial data: regulatory failure and the uses of legal ambiguity" ), ''Journal of Medical Ethics'', 35(2), February 2009, pp. 107–112. PMID 19181884 Le Noury, Joanna, et al. ("Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence" ), ''BMJ'', 351, 16 September 2015. PMID 26376805〕 Marketing of the drug began in 1992 by the pharmaceutical company SmithKline Beecham, known since 2000 as GlaxoSmithKline. Generic formulations have been available since 2003 when the patent expired. The United States Department of Justice fined GlaxoSmithKline $3 billion in 2012, including a sum for withholding data on paroxetine, unlawfully promoting it for the under-18s, and preparing an article, following one of its clinical trials, study 329, that misleadingly reported the drug was effective in treating adolescent depression. ==Medical uses== Paroxetine is primarily used to treat major depression, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), panic disorder, generalized anxiety disorder (GAD), social phobia/social anxiety disorder, premenstrual dysphoric disorder (PMDD) and menopausal hot flashes. Paroxetine was the first antidepressant formally approved in the United States for the treatment of panic attacks. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Paroxetine」の詳細全文を読む スポンサード リンク
|