翻訳と辞書 Words near each other ・ Pseudagrion spernatum ・ Pseudagrion sublacteum ・ Pseudagrion sudanicum ・ Pseudagrion superbum ・ Pseudagrion torridum ・ Pseudagrion vumbaense ・ Pseudagrostistachys ・ Pseudagrostistachys africana ・ Pseudalastor ・ Pseudalbara ・ Pseudalbara fuscifascia ・ Pseudalbara parvula ・ Pseudalcathoe ・ Pseudalcis ・ PSEmu Pro ・ PSEN1 ・ PSEN2 ・ Psenes ・ Psenicubiceps ・ Psenocerus supernotatus ・ Psenopsis ・ Psephis ・ Psephis gomalis ・ Psephis ministralis ・ Psephis myrmidonalis ・ Psephite ・ Psephochelys ・ Psephoderma ・ Psepholograph ・ Psephology Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク PSEN1 ： ウィキペディア英語版 PSEN1 Presenilin-1 (PS-1) is a protein that in humans is encoded by the ''PSEN1'' gene. Presenilin 1 is one of the four core proteins in presenilin complex, which mediate the regulated proteolytic events of several proteins in the cell, including gamma secretase. Gamma-secretase is considered to play a very important role in generation of beta amyloid, accumulation of which is related to the onset of Alzheimer's Disease, from the beta-amyloid precursor protein. == Structure == Presenilin possesses a 9 transmembrane topology, with an extracellular C-terminus and a cytosolic N-terminus. Presenilin is subject to undergo endo-proteolytic processing to produce ~27-28 kDa N-terminal and ~16-17 kDa C-terminal fragments in humans. Furthermore, presenilin exists in the cell mainly as a heterodimer of the C-terminal and N-terminus fragments.〔 When presenilin 1 is over expressed, the full length protein accumulates in an inactive form. Based on evidence that a gamma-secretase inhibitor binds to the fragments, the cleaved presenilin complex is considered to be the active form. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「PSEN1」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.