翻訳と辞書 Words near each other ・ Pink-headed imperial pigeon ・ Pink-headed warbler ・ Pink-legged graveteiro ・ Pink-legged rail ・ Pink-necked green pigeon ・ Pink-Pigmented Facultative Methylotrophs ・ Pink-rumped rosefinch ・ Pink-sided tree frog ・ Pink-speckled shrimpgoby ・ Pink-spotted fruit dove ・ Pink-tailed worm-lizard ・ Pink-throated becard ・ Pink-throated brilliant ・ Pink-throated twinspot ・ Pink-winged phasma ・ PINK1 ・ Pinka ・ Pinka, Greater Poland Voivodeship ・ Pinkafeld ・ Pinkafeld Airport ・ Pinkalicious ・ Pinkamindszent ・ Pinkan Mambo ・ Pinkard & Bowden ・ Pinkas ・ Pinkas (surname) ・ Pinkas Braun ・ Pinkas haKehilot ・ Pinkas Synagogue ・ Pinkasim Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク PINK1 ： ウィキペディア英語版 PINK1 PTEN-induced putative kinase 1 (PINK1) is a mitochondrial serine/threonine-protein kinase encoded by the ''PINK1'' gene. It is thought to protect cells from stress-induced mitochondrial dysfunction. PINK1 activity causes the parkin protein to bind to depolarized mitochondria to induce autophagy of those mitochondria. PINK1 is processed by healthy mitochondria and released to trigger neuron differentiation. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson's disease.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=65018 )〕 == Structure == PINK1 is synthesized as a 63000 Da protein which is often cleaved by PARL, between the 103-Alanine and the 104-Phenylalanine residues, into a 53000 Da fragment. PINK1 contains an N-terminal mitochondrial localization sequence, a putative transmembrane sequence, a Ser/Thr kinase domain, and a C-terminal regulatory sequence. The protein has been found to localize to the outer membrane of mitochondria, but can also be found throughout the cytosol. Experiments suggest the Ser/Thr kinase domain faces outward toward the cytosol, indicating a possible point of interaction with parkin. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「PINK1」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.