翻訳と辞書 Words near each other ・ Phlox glabriflora ・ Phlox hirsuta ・ Phlox hoodii ・ Phlox nivalis ・ Phlox paniculata ・ Phlox pilosa ・ Phlox pulvinata ・ Phlox speciosa ・ Phlox stansburyi ・ Phlox stolonifera ・ Phlox subulata ・ Phlox tenuifolia ・ Phlox, Indiana ・ Phlox, Wisconsin ・ Phloxine ・ PHLPP ・ PHLPP (gene) ・ PHLPPL ・ PHLX Semiconductor Sector ・ Phlyaria ・ Phlyarus ・ Phlyax play ・ Phlyctaeniidae ・ Phlyctaenius ・ Phlyctaenodini ・ Phlyctaenogastra ・ Phlyctaenogastra britae ・ Phlyctaenogastra familia ・ Phlyctaenogastra rangei ・ Phlyctaenomorpha Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク PHLPP ： ウィキペディア英語版 PHLPP The PHLPP isoforms (PH domain and Leucine rich repeat Protein Phosphatases) are a pair of protein phosphatases, PHLPP1 and PHLPP2, that are important regulators of Akt serine-threonine kinases (Akt1, Akt2, Akt3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP may act as a tumor suppressor in several types of cancer due to its ability to block growth factor-induced signaling in cancer cells. PHLPP dephosphorylates Ser-473 (the hydrophobic motif) in Akt, thus partially inactivating the kinase. In addition, PHLPP dephosphorylates conventional and novel members of the protein kinase C family at their hydrophobic motifs, corresponding to Ser-660 in PKCβII. == Domain structure == PHLPP is a member of the PPM family of phosphatases, which requires magnesium or manganese for their activity and are insensitive to most common phosphatase inhibitors, including (acid ). PHLPP1 and PHLPP2 have a similar domain structure, which includes a putative Ras association domain, a pleckstrin homology domain, a series of leucine-rich repeats, a PP2C phosphatase domain, and a C-terminal PDZ ligand. PHLPP1 has two splice variants, PHLPP1α and PHLPP1β, of which PHLPP1β is larger by approximately 1.5 kilobase pairs. PHLPP1α, which was the first PHLPP isoform to be characterized, lacks the N-terminal portion of the protein, including the Ras association domain.〔 PHLPP's domain structure influences its ability to dephosphorylate its substrates. A PHLPP construct lacking the PH domain is unable to decrease PKC phosphorylation, while PHLPP lacking the PDZ ligand is unable to decrease Akt phosphorylation.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「PHLPP」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.