翻訳と辞書 Words near each other ・ Peștiș River (Mureș) ・ Peștiș River (Topa) ・ Peștișani ・ Peța River ・ Pe̍h-ōe-jī ・ PF ・ PF (firewall) ・ PF Flyers ・ PF Magic ・ PF Schio ・ PF Tek ・ PF Umbertide ・ PF-00446687 ・ PF-03550096 ・ PF-03654746 ・ PF-04457845 ・ PF-05089771 ・ PF-184563 ・ PF-219,061 ・ PF-2545920 ・ PF-3845 ・ PF-4455242 ・ PF-4800567 ・ PF-4840154 ・ PF-514273 ・ PF-592,379 ・ PF-89 ・ PF-9 ・ PF-98 ・ PF1 Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク PF-04457845 ： ウィキペディア英語版 PF-04457845 PF-04457845 is a potent and exquisitely selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), with an IC50 of 7.2nM, and both analgesic and antiinflammatory effects in animal studies comparable to naproxen. It has been well tolerated in human trials even at high dose ranges with no evidence for cognitive dysfunction, and has completed Phase II clinical trials for the treatment of osteoarthritis,〔Ahn K, Smith SE, Liimatta MB, Beidler D, Sadagopan N, Dudley DT, Young T, Wren P, Zhang Y, Swaney S, Van Becelaere K, Blankman JL, Nomura DK, Bhattachar SN, Stiff C, Nomanbhoy TK, Weerapana E, Johnson DS, Cravatt BF. Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain. ''Journal of Pharmacology and Experimental Therapeutics''. 2011 Jul;338(1):114-24. PMID 21505060〕〔(A Study To Investigate Whether PF-04457845 Is Effective In Treating Pain, Is Safe And Tolerable In Patients With Osteoarthritis Of The Knee )〕 but was found to be ineffective. == See also == * 4-Nonylphenylboronic acid * LY-2183240 * URB-597 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「PF-04457845」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.