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Poly () polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly() synthase 1 is an enzyme that in humans is encoded by the ''PARP1'' gene. == Function == PARP1 works: * By modifying nuclear proteins by poly ADP-ribosylation. * In conjunction with BRCA, which acts on double strands; members of the PARP family act on single strands; or, when BRCA fails, PARP takes over those jobs as well. PARP1 is involved in: * Differentiation, proliferation, and tumor transformation * Normal or abnormal recovery from DNA damage * May be the site of mutation in Fanconi anemia * May participate in the pathophysiology of type I diabetes.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=142 )〕 PARP1 is activated by: * Helicobacter pylori in the development and proliferation of gastric cancer. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「PARP1」の詳細全文を読む スポンサード リンク
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