|
Oxyhyperglycemia is a special type of Impaired glucose tolerance characterized by a rapid and transient hyperglycemia (ie rise in blood glucose) spike after an oral intake of glucose, the peak of this spike being high enough to cause transient, symptom free glycosuria (i.e. detectable glucose in urine), but this hyperglycemia reverses rapidly and may even go to hypoglycemia in the later phase. This sharp downstroke overshooting towards hypoglycemia distinguishes this pathologic phenomenon from the artificial hyperglycemia inducible by an intravenous bolus dose of a large amount of glucose solution. Early dumping syndrome patients usually have oxyhyperglycemia associated with any meal or OGTT. The Greek root ''oxy'' means "sharp" or "pointy".〔http://wordquests.info/cgi/ice2-for.cgi?file=/hsphere/local/home/scribejo/wordquests.info/htm/L-Gk-oxy-O-P.htm&HIGHLIGHT=oxy〕〔List of Greek and Latin roots in English〕 The OGTT curve in this condition appears sharp and somewhat pointy (at least relative to the other forms of hyperglycemia)- hence this name. Dorlands dictionary defines oxyhyperglycemia as:〔Dorland's Illustrated Medical Dictionary E-Book Elsevier Health Sciences, 2 May 2011 - 2176 pages http://books.google.co.in/books?id=mNACisYwbZoC&pg=PT6008&lpg=PT6008&dq=oxyhyperglycemia+glycosuria&source=bl&ots=aX7RNVcZk0&sig=kPMLuW1Ftdeiiz3WPuSGAT90U1w&hl=en&sa=X&ei=qeKWT7bdBcHlrAeQn5yDDg&ved=0CGEQ6AEwCA#v=onepage&q=oxyhyperglycemia%20glycosuria&f=false〕 :"A condition in which there is slight glycosuria and an Oral Glucose Tolerance curve that rises about 180-200 mg/dL but returns to fasting value 2.5 hrs after ingestion of the glucose." A blood level of approximately 180 mg/dL is the renal glucose threshold below which all glucose is reabsorbed from glomerular filtrate. But at blood concentrations above the renal threshold sugar starts appearing in the urine. Oxyhyperglycemia, like other forms of Impaired glucose tolerance has also been suggested to be a prediabetic condition〔Takayoski Tobe; Mamoru Kouchi; Hiroshi Tanimura; Chiu Hsiung Huang Hyperglycemia After Gastrectomy as a Prediabetic State: Clinical Study of 100 Postgastrectomy Patients AMA Arch Surg. 1967;94(6):836-840. http://archsurg.ama-assn.org/cgi/content/summary/94/6/836〕 ==Usual cause== Oxyhyperglycemia is most commonly caused by early dumping syndrome, but it can rarely caused by other conditions like Graves' disease.〔Nagoya J Med Sci. 1994 Mar;57(1-4):61-8. Glucose and insulin metabolism in patients with hyperthyroidism due to Graves' disease. Mano T, Kawakubo A, Yamamoto M. http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5712/v57n12p61_68.pdf〕 It was first described by Lawrence et al in 1936〔Lawrence, R.D.: Symptomless Glycosurias: Differentiation by Sugar Tolerance Tests , Med Clin N Amer 31:289, 1947〕〔Tobe T, Kouchi M, Tanimura H, Huang C. Hyperglycemia after gastrectomy as a prediabetic stateclinical study of 100 postgastrectomy patients. Arch Surg. 1967;94(6):836-840.〕 as often happening after gastroenterostomy. It is seen in most forms of gastrectomy, gastric bypass and gastrostomy procedures, all of which are surgical causes of dumping syndrome. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Oxyhyperglycemia」の詳細全文を読む スポンサード リンク
|