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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Oxibendazole ： ウィキペディア英語版 Oxibendazole Oxibendazole is a benzimidazole drug that is used to protect against roundworms, strongyles, threadworms, pinworms and lungworm infestations in horses and some domestic pets. It is usually white to yellowish in appearance, and may take the form of a powder or a tablet. ==Synthesis== 4-Hydroxyacetamide is alkylated with ''n''-propylbromide in the presence of KOH to give the ether (2). Nitration of the product with HNO3/H2SO4 proceeds at the position ortho to the amido group (3); saponification followed by reduction of the nitro group with SnCl2gives the phenylenediamine (4). Reaction of that intermediate with S-methylthiourea can be visualized as proceeding first to the guanidine obtained by addition to the imine double bond followed by elimination of methyl mercaptan. Cyclization completes the construction of the 2-aminobenzimidazole system. Acylation with methyl chloroformate results in the formation of a urethane on the amino group to produce 6. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Oxibendazole」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.