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Noribogaine : ウィキペディア英語版
Noribogaine

Noribogaine, or 12-hydroxyibogamine, is the principal psychoactive metabolite of the psychedelic drug ibogaine. It is thought to be involved in the anti-addictive effects of ibogaine-containing plant extracts.
A recent study evaluated its effects on healthy volunteers at doses of 3–60 mg, finding no tolerability issues. A slow half-life of 28–49 hours was seen with large volume of distribution.
== Pharmacology ==
Noribogaine inhibits serotonin uptake more than ibogaine but does not affect dopamine. It has greater affinity for serotonin transporters and less at sigma-2 receptors. In binding studies noribogaine has a greater affinity at each opioid receptor than ibogaine.
Ki-values in μM

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Noribogaine」の詳細全文を読む



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