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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Norgestimate ： ウィキペディア英語版 Norgestimate Norgestimate (INN, USAN, BAN) is an acetylated progestin used as an oral contraceptive. It acts as a prodrug to norelgestromin (17-deacetylnorgestimate or levonorgestrel 3-oxime), the primary active metabolite, and levonorgestrel (deacetylation of norgestimate occurs in the intestines and the liver).〔 Unlike levonorgestrel, norgestimate shows high selectivity for the progesterone receptor and low androgenic action due to a large drug-induced elevation in the level of sex hormone-binding globulin (SHBG) (which preferentially binds androgens and thus inhibits their action).〔 In accordance, clinical trials have observed minimal androgenic side effects.〔 Norgestimate and its metabolites themselves, unlike many other progestins, do not bind to SHBG.〔 Norgestimate is used in combination with ethinyl estradiol as an oral contraceptive.〔: Ortho Tri-Cyclen〕 ==See also== * Desogestrel 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Norgestimate」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.