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Netpath
NetPath is a manually curated resource of human signal transduction pathways. It is a joint effort between Pandey Lab at the Johns Hopkins University and the Institute of Bioinformatics (IOB), Bangalore, India,〔(Dr. Akhilesh Pandey's laboratory )〕 and is also worked on by other parties.
NetPath hosts 20 signaling pathways including 10 pathways with a major role in the regulation of immune system and 10 pathways with relevance to regulation of cancer.
==Overview==
The 20 pathways contain information pertaining to protein-protein interactions, enzyme-protein substrate reactions which bring about post translational modifications (PTMs) and also a catalogue of genes which are differentially regulated upon activation of specific ligand mediated receptor pathways. The molecules which localises to different cellular organelles due to their PTMs or specific protein-protein interactions which occur downstream of ligand-receptor mediated pathway are available under translocation events. Recently, NetPath has also curated the molecules involved in the transcriptional regulation of genes in the context of immune signaling pathways. The reactions in NetPath are curated by PhD level scientists from experimental evidence available in published research articles. NetPath also contains textual description of its reactions with information on PTMs, dependence of PTMs on various signaling reactions, subcellular location, protein interaction domains or motifs and the cell type or cell line in which reactions are proved. The information in NetPath is linked to their corresponding research articles and are frequently updated. Each pathway is subjected to different level of internal quality checks and peer-review by the pathway experts and authorities.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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