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Nucleophosmin (NPM), also known as nucleolar phosphoprotein B23 or numatrin, is a protein that in humans is encoded by the ''NPM1'' gene. == Function == NPM1 is associated with nucleolar ribonucleoprotein structures and bind single-stranded and double-stranded nucleic acids, but it binds preferentially G-Quadruplex forming nucleic acids. It is involved in the biogenesis of ribosomes and may assist small basic proteins in their transport to the nucleolus. Its regulation through SUMOylation (by SENP3 and SENP5) is another facet of the proteins's regulation and cellular functions. It is located in the nucleolus, but it can be translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. The protein is phosphorylated. Nucleophosmin has multiple functions: # Histone chaperons # Ribosome biogenesis and transport # Genomic stability and DNA repair # Endoribonuclease activity # Centrosome duplication during cell cycle # Regulation of ARF-p53 tumor suppressor pathway # RNA helix destabilizing activity # Inhibition of caspase-activated DNase # Prevents apoptosis when located in nucleolus 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「NPM1」の詳細全文を読む スポンサード リンク
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