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Myophosphorylase
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Myophosphorylase : ウィキペディア英語版
Myophosphorylase

Myophosphorylase is the muscle isoform of the enzyme ''glycogen phosphorylase''. This enzyme helps break down glycogen (a form of stored carbohydrate) into glucose-1-phosphate (not glucose), so that it can be utilized within the muscle cell.
==Clinical significance==
A deficiency is associated with Glycogen storage disease type V, also known as "McArdle's Syndrome".

A case study suggested that a deficiency in myophosphorylase may be linked with cognitive impairment. Besides muscle, this isoform is present in astrocytes, where it plays a key role in neural energy metabolism. A 55-year-old woman with McArdle disease has expressed cognitive impairment with bilateral dysfunction of prefrontal and frontal cortex. Further studies are needed to assess the validity of this claim.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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