翻訳と辞書 Words near each other ・ Moyaux ・ Moybeg Kirley ・ Moycarkey ・ Moycarkey (disambiguation) ・ Moycarkey (electoral division) ・ Moycarkey Castle ・ Moycarkey, Littleton, Two-Mile-Borris ・ Moycarkey-Borris GAA ・ Mox Peaks ・ Mox-Linde Gases ・ Moxa ・ Moxahala Creek ・ Moxahala, Ohio ・ Moxastine ・ Moxaverine ・ Moxazocine ・ Moxby Priory ・ MOXE ・ Moxee, Washington ・ Moxestrol ・ Moxetumomab pasudotox ・ Moxey ・ Moxham ・ Moxham Historic District ・ Moxhull Hall ・ Moxi ・ Moxi Town ・ Moxibustion ・ Moxico ・ Moxico Province Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Moxazocine ： ウィキペディア英語版 Moxazocine Moxazocine (BL-4566) is an opioid analgesic of the benzomorphan family which was never marketed. It acts as a partial agonist or mixed agonist/antagonist of the opioid receptors and binds preferentially to the κ-opioid receptor. Despite its failure to reach the market, clinical studies demonstrated moxazocine to be approximately 10x as potent by weight as morphine as an analgesic. ==Synthesis== Reduction of the carbonyl group in oxygenated benzomorphan 1 affords the corresponding alcohol (2). This intermediate is then N-demethylated by means of BrCN. Acylation with cyclopropylcarbonyl chloride〔http://caod.oriprobe.com/articles/6521356/Synthesis_of_Cyclopropanecarbonyl_chloride.htm〕 gives the amide (3). The alcohol is then converted to the ether by treatment with MeI and base (4). Treatment with LiAlH4 serves to reduce the amide function. Cleavage of the phenolic ether by one of the standard schemes affords moxazocine (6). 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Moxazocine」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.