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Methocarbamol
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Methocarbamol : ウィキペディア英語版
Methocarbamol

Methocarbamol is a central muscle relaxant used to treat skeletal muscle spasms. Under the trade name Robaxin, it is marketed by Actient Pharmaceuticals in the United States and Pfizer in Canada. The mechanism of action of methocarbamol is currently unknown, but may involve the inhibition of carbonic anhydrase. The muscle relaxant effects of methocarbamol are largely attributed to central depressant effects; however, peripheral effects of methocarbamol to prolong muscle refractory period have also been reported.
==Metabolism==
Methocarbamol is the carbamate of guaifenesin, but does not produce guaifenesin as a metabolite, because the carbamate bond is not hydrolyzed metabolically; metabolism is by Phase I ring hydroxylation and ''O''-demethylation, followed by Phase II conjugation. All the major metabolites are unhydrolyzed carbamates.〔Methocarbamol. In: ''DRUGDEX System'' (database ). Greenwood Village, Colorado: Thomson Healthcare; c1974–2009 (2009 Feb 10 ).〕

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