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・ MLSSA
・ MLST8
・ MLSTD2
・ MLT
・ MLT-3 encoding
・ MLton
・ MLTR (album)
・ Mlečva
・ Mleščevo
・ MLF
・ MLF1
・ MLF1IP
・ MLG
・ MLH
・ MLH1
MLH3
・ MLHS
・ MLI
・ MLI-84
・ MLIA
・ Mlib Tmetuchl
・ Mliba
・ Mlibizi
・ Mlibo Ngewu
・ Mlice-Kostery
・ Mliha
・ Mlik
・ Mlilot
・ Mlilwane Wildlife Sanctuary
・ Mlima Combani and Mlima Mtsapéré Important Bird Area


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MLH3 : ウィキペディア英語版
MLH3

DNA mismatch repair protein Mlh3 is a protein that in humans is encoded by the ''MLH3'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27030 )
== Function ==

This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.〔 Orthologs of human MLH3 have also been studied in other organisms including mouse and the budding yeast ''Saccharomyces cerevisiae''.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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