翻訳と辞書
Words near each other
・ Luther Burbank School District
・ Luther Burbank's Gold Ridge Experiment Farm
・ Luther Burden
・ Luther Burger
・ Luther Burleson
・ Luther Burrell
・ Luther C. Carter
・ Luther C. Ladd
・ Luther C. Peck
・ Luther C. Tibbets
・ Luther Campbell
・ Luther Carrington Goodrich
・ Luther Christman
・ Luteimonas vadosa
・ Lutein
Luteinizing hormone
・ Luteinizing hormone beta polypeptide
・ Luteinizing hormone/choriogonadotropin receptor
・ Lutek
・ Lutel James
・ Lutelu Tiute
・ Lutembacher's syndrome
・ Lutembe Bay
・ Luten arch
・ Luten Bridge Company
・ Luteoforol
・ Luteohadena
・ Luteolejeunea
・ Luteolejeunea herzogii
・ Luteolin


Dictionary Lists
翻訳と辞書 辞書検索 [ 開発暫定版 ]
スポンサード リンク

Luteinizing hormone : ウィキペディア英語版
Luteinizing hormone

Luteinizing hormone (LH, also known as lutropin and sometimes lutrophin) is a hormone produced by gonadotropic cells in the anterior pituitary gland. In females, an acute rise of LH ("LH surge") triggers ovulation and development of the corpus luteum. In males, where LH had also been called interstitial cell–stimulating hormone (ICSH), it stimulates Leydig cell production of testosterone.〔 It acts synergistically with FSH.
== Structure ==

LH is a heterodimeric glycoprotein. Each monomeric unit is a glycoprotein molecule; one alpha and one beta subunit make the full, functional protein.
Its structure is similar to that of the other glycoprotein hormones, follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and human chorionic gonadotropin (hCG). The protein dimer contains 2 glycopeptidic subunits, labeled alpha and beta subunits, that are non-covalently associated (i.e., without any disulfide bridge linking them):
* The ''alpha subunits'' of LH, FSH, TSH, and hCG are identical, and contain 92 amino acids in human but 96 amino acids in almost all other vertebrate species (glycoprotein hormones do not exist in invertebrates).
* The ''beta subunits'' vary. LH has a beta subunit of 120 amino acids (LHB) that confers its specific biologic action and is responsible for the specificity of the interaction with the LH receptor. This beta subunit contains an amino acid sequence that exhibits large homologies with that of the beta subunit of hCG and both stimulate the same receptor. However, the hCG beta subunit contains an additional 24 amino acids, and the two hormones differ in the composition of their sugar moieties.
The different composition of these oligosaccharides affects bioactivity and speed of degradation. The biologic half-life of LH is 20 minutes, shorter than that of FSH (3–4 hours) and hCG (24 hours).

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Luteinizing hormone」の詳細全文を読む



スポンサード リンク
翻訳と辞書 : 翻訳のためのインターネットリソース

Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.