翻訳と辞書 Words near each other ・ Lonicera interrupta ・ Lonicera involucrata ・ Lonicera japonica ・ Lonicera ligustrina ・ Lonicera maackii ・ Lonicera morrowii ・ Lonicera nitida ・ Lonicera periclymenum ・ Lonicera pileata ・ Lonicera sempervirens ・ Lonicera subspicata ・ Lonicera tatarica ・ Lonicera utahensis ・ Lonicera xylosteum ・ Lonicera × heckrottii ・ Lonidamine ・ Lonie ・ Lonie Paxton ・ Lonie Report ・ Lonigo ・ Lonimavla Dam ・ Lonimawala ・ Lonin Museum of Veps Ethnography ・ Loningisa ・ Loniu language ・ Lonja ・ Lonja del Comercio building ・ Lonjin ・ Lonjsko Polje ・ Lonjé Molen, Bolsward Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Lonidamine ： ウィキペディア英語版 Lonidamine Lonidamine is a derivative of indazole-3-carboxylic acid, which for a long time, has been known to inhibit aerobic glycolysis in cancer cells. It seems to enhance aerobic glycolysis in normal cells, but suppress glycolysis in cancer cells. This is most likely through the inhibition of the mitochondrially bound hexokinase. Later studies in Ehrlich ascites tumor cells showed that lonidamine inhibits both respiration and glycolysis leading to a decrease in cellular ATP. Clinical trials of lonidamine in combination with other anticancer agents for a variety of cancers has begun. This is due to its proven ability to inhibit energy metabolism in cancer cells, and to enhance the activity of anticancer agents.〔 Lonidamine has been used in the treatment of brain tumours in combination with radiotherapy and temozolomide. Results showed that a combination of temozolomide and lonidamine at clinically achievable, low plasma concentrations, could inhibit tumour growth, and lonidamine could reduce the dose of temozolomide required for radiosensitization of brain tumours. A derivative of lonidamine, gamendazole, is in testing as a possible male contraceptive pill. ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Lonidamine」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.