翻訳と辞書 Words near each other ・ KCSP (AM) ・ KCSP-FM ・ KCSR ・ KCSS ・ KCSS (FM) ・ KCST ・ KCST-FM ・ KCSU ・ KCSU-FM ・ KCSW-LP ・ KCNN4 ・ KCNO ・ KCNP ・ KCNQ ・ KCNQ1DN ・ KCNQ1OT1 ・ KCNQ4 ・ KCNQ5 ・ KCNR ・ KCNRG ・ KCNS ・ KCNS1 ・ KCNS2 ・ KCNS3 ・ KCNT ・ KCNT1 ・ KCNT2 ・ KCNU1 ・ KCNV ・ KCNV1 Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク KCNQ1OT1 ： ウィキペディア英語版 KCNQ1OT1 KCNQ1 overlapping transcript 1, also known as KCNQ1OT1, is a long non-coding RNA gene found in the KCNQ1 locus. This locus consists of 8-10 protein-coding genes, specifically expressed from the maternal allele (including the KCNQ1 gene), and the paternally expressed non-coding RNA gene KCNQ1OT1. KCNQ1OT1 is a nuclear, 91 kb transcript, found in close proximity to the nucleolus in certain cell types. It interacts with chromatin, the histone methyltransferase G9a (responsible for the mono- and dimethylation of histone 3 lysine 9, H3K9), and the Polycomb Repressive Complex 2, PRC2, (responsible for the trimethylation of H3K27).〔 It plays an important role in the transcriptional silencing of the KCNQ1 locus by regulating histone methylation.〔 An 890 bp region at the 5' end of KCNQ1OT1 acts as a silencing domain. This region regulates CpG methylation levels of somatically acquired differentially methylated regions (DMRs), mediates the interaction of KCNQ1OT1 with chromatin and with DNA (cytosine-5)-methyltransferase 1 (DNMT1), but does not affect the interactions of histone methyltransferases with KCNQ1OT1.〔 ==See also== * Long noncoding RNA * Beckwith-Wiedemann syndrome 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「KCNQ1OT1」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.