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・ JWH-184
・ JWH-185
・ JWH-193
・ JWH-196
・ JWH-198
・ JWH-200
・ JWH-203
・ JWH-210
・ JWH-249
・ JWH-250
・ JWH-251
・ JWH-302
・ JWH-307
・ JWH-359
・ JWH-398
JWH-424
・ Jwibulnori
・ Jwipo
・ Jwira-Pepesa language
・ JWK
・ JWL
・ JWL standard
・ JWM
・ JWM Partners
・ JWN
・ JWoww
・ JWP
・ JWP Joshi Puroresu
・ JWP Junior and Princess of Pro-Wrestling Championships
・ JWP Openweight Championship


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JWH-424 : ウィキペディア英語版
JWH-424

JWH-424 is a drug from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors, but with moderate selectivity for CB2, having a Ki of 5.44nM at CB2 vs 20.9nM at CB1. The heavier 8-iodo analogue is even more CB2 selective, with its 2-methyl derivative having 40x selectivity for CB2. However the 1-propyl homologues in this series showed much lower affinity at both receptors, reflecting a generally reduced affinity for the 8-substituted naphthoylindoles overall.〔Valerie Smith, John Huffman, Jenny Wiley and Billy Martin. EFFECTS OF HALOGEN SUBSTITUENTS UPON CB1 AND CB2 RECEPTOR AFFINITIES IN THE SERIES OF N-ALKYL-3-(8-HALO-1-NAPTHOYL)INDOLES. (2007) 17th Annual Symposium on the Cannabinoids, Burlington, Vermont, International Cannabinoid Research Society, Page 72.〕〔John W. Huffman, ''et al.'' STRUCTURE-ACTIVITY RELATIONSHIPS AT THE CB1 AND CB2 RECEPTORS FOR 1-ALKYL-3-(1-NAPHTHOYL-4 AND 8-HALOGEN SUBSTITUTED) INDOLES (2009) 19th Annual Symposium on the Cannabinoids, Burlington, Vermont, International Cannabinoid Research Society, Page 2.〕
==See also==

* JWH-018
* JWH-398

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「JWH-424」の詳細全文を読む



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