翻訳と辞書
Words near each other
・ Jyothirgamaya
・ Jyothirgamaya foundation
・ Jyothirmayi
・ Jyothishmathi College of Engineering and Technology
・ Jyothy Kendriya Vidyalaya
・ Jyothy Laboratories
・ JWH-098
・ JWH-116
・ JWH-120
・ JWH-122
・ JWH-133
・ JWH-147
・ JWH-148
・ JWH-149
・ JWH-161
JWH-164
・ JWH-167
・ JWH-175
・ JWH-176
・ JWH-184
・ JWH-185
・ JWH-193
・ JWH-196
・ JWH-198
・ JWH-200
・ JWH-203
・ JWH-210
・ JWH-249
・ JWH-250
・ JWH-251


Dictionary Lists
翻訳と辞書 辞書検索 [ 開発暫定版 ]
スポンサード リンク

JWH-164 : ウィキペディア英語版
JWH-164

JWH-164 is a synthetic cannabinoid receptor agonist from the naphthoylindole family. It has approximately equal affinity for the CB1 and CB2 receptors, with a Ki of 6.6nM at CB1 and 6.9nM at CB2. JWH-164 is a positional isomer of the related compound JWH-081, but with a methoxy group at the 7-position of the naphthyl ring, rather than the 4-position as in JWH-081. Its potency is intermediate between that of JWH-081 and its ring unsubstituted derivative JWH-018, demonstrating that substitution of the naphthyl 7-position can also result in increased cannabinoid receptor binding affinity.〔Huffman JW, ''et al.'' Structure–activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB1 and CB2 receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB2 receptor agonists. ''Bioorganic and Medicinal Chemistry''. 2005; 13:89-112. PMID 15582455〕〔Huffman JW, Padgett LW. Recent Developments in the Medicinal Chemistry of Cannabimimetic Indoles, Pyrroles and Indenes. ''Current Medicinal Chemistry'', 2005; 12: 1395-1411. PMID 15974991〕
==References==



抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「JWH-164」の詳細全文を読む



スポンサード リンク
翻訳と辞書 : 翻訳のためのインターネットリソース

Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.